Ontology highlight
ABSTRACT:
SUBMITTER: King D
PROVIDER: S-EPMC7289530 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
King David D Li Xiao Dun XD Almeida Gilberto S GS Kwok Colin C Gravells Polly P Harrison Daniel D Burke Saoirse S Hallsworth Albert A Jamin Yann Y George Sally S Robinson Simon P SP Lord Christopher J CJ Poon Evon E Yeomanson Daniel D Chesler Louis L Bryant Helen E HE
Oncotarget 20200609 23
This study investigates the influence expression of the MYCN oncogene has on the DNA damage response, replication fork progression and sensitivity to PARP inhibition in neuroblastoma. In a panel of neuroblastoma cell lines, <i>MYCN</i> amplification or MYCN expression resulted in increased cell death in response to a range of PARP inhibitors (niraparib, veliparib, talazoparib and olaparib) compared to the response seen in non-expressing/amplified cells. MYCN expression slowed replication fork sp ...[more]