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Impact of Different Sampling Schemes for Decision Making in Soil-Transmitted Helminthiasis Control Programs.


ABSTRACT: Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individuals, thereby lowering the statistical precision of prevalence estimates. Using population-level data from various epidemiological settings, we assessed the performance of different sampling schemes executed within the confines of the same budget. We recommend the use of single-slide KK for determining prevalence of moderate-to-heavy intensity infection and policy decisions for starting and continuing PC; more sensitive sampling schemes may be required for policy decisions involving stopping PC. Our findings highlight that guidelines should include specific guidance on sampling schemes.

SUBMITTER: Coffeng LE 

PROVIDER: S-EPMC7289558 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Impact of Different Sampling Schemes for Decision Making in Soil-Transmitted Helminthiasis Control Programs.

Coffeng Luc E LE   Malizia Veronica V   Vegvari Carolin C   Cools Piet P   Halliday Katherine E KE   Levecke Bruno B   Mekonnen Zeleke Z   Gichuki Paul M PM   Sayasone Somphou S   Sarkar Rajiv R   Shaali Ame A   Vlaminck Johnny J   Anderson Roy M RM   de Vlas Sake J SJ  

The Journal of infectious diseases 20200601 Suppl 5


Starting and stopping preventive chemotherapy (PC) for soil-transmitted helminthiasis is typically based on the prevalence of infection as measured by Kato-Katz (KK) fecal smears. Kato-Katz-based egg counts can vary highly over repeated stool samples and smears. Consequentially, the sensitivity of KK-based surveys depends on the number of stool samples per person and the number of smears per sample. Given finite resources, collecting multiple samples and/or smears means screening fewer individua  ...[more]

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