Ontology highlight
ABSTRACT:
SUBMITTER: Droin C
PROVIDER: S-EPMC7289635 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Droin Colas C Paquet Eric R ER Naef Felix F
Nature physics 20190805 10
The circadian clock and the cell cycle are two biological oscillatory processes that coexist within individual cells. These two oscillators were found to interact, which can lead to their synchronization. Here, we develop a method to identify a low-dimensional stochastic model of the coupled system directly from time-lapse imaging in single cells. In particular, we infer the coupling and non-linear dynamics of the two oscillators from thousands of mouse and human single-cell fluorescence microsc ...[more]