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Lockdown for COVID-19 and its impact on community mobility in India: An analysis of the COVID-19 Community Mobility Reports, 2020.

ABSTRACT: Background:Coronavirus disease (COVID-19) is a novel public health problem threatening the whole world. As an upshot, countrywide lockdown due to COVID-19 pandemic has been supportive of changing community mobility trends of various place categories including retail and recreation, groceries and pharmacies, parks, transit stations, workplaces, and residential in India. Objective:To analyze the impact of lockdown for COVID-19 on community mobility using spatial time-series change over different states and union territories (UTs) of India. Data & Methods:This study has been organized based on states & UTs wise time-series data of the daily percentage of change of community mobility from baseline in India, collected from 15th February to 30th April 2020. Conditional formatting techniques, time-series trends plotting method, spatial inverse distance weighted (IDW) interpolation mapping techniques have been employed to show pre and post lockdown mobility trends due to COVID-19 i.e. to fulfill the objective. Results:Across India, retail and recreation, grocery and pharmacy, visits to parks, transit stations, and workplaces mobility dropped by -73.4%, -51.2%, -46.3%, -66% and -56.7% respectively. Visits to residential places mobility increased by 23.8% as people mostly stayed home during the lockdown. The COVID-19 lockdown started on 24 March 2020 and just gone one day (March 25, 2020) of the beginning of lockdown, there have a decreased in percentage (-70.51% in retail and recreation mobility), (-64.26% in grocery and pharmacy mobility), (-46.17% in parks mobility), (-65.6% in transit stations mobility), (-60.03% in workplaces mobility) from baseline in compared to the pre-lockdown period and residential mobility has been increased in percentage (26.32%) from baseline due to people stayed home during the lockdown for COVID-19 pandemic in India. Conclusion:Study figures out mobility trends over time during pre-lockdown and after lockdown period across different categories of places such as retail and recreation, groceries and pharmacies, parks, transit stations, workplaces, and residential, which can be used in public health strategies to drop the spread of COVID-19.

SUBMITTER: Saha J

PROVIDER: S-EPMC7289746 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Lockdown for COVID-19 and its impact on community mobility in India: An analysis of the COVID-19 Community Mobility Reports, 2020.

Saha Jay J Barman Bikash B Chouhan Pradip P

Children and youth services review 20200612

<h4>Background</h4>Coronavirus disease (COVID-19) is a novel public health problem threatening the whole world. As an upshot, countrywide lockdown due to COVID-19 pandemic has been supportive of changing community mobility trends of various place categories including retail and recreation, groceries and pharmacies, parks, transit stations, workplaces, and residential in India.<h4>Objective</h4>To analyze the impact of lockdown for COVID-19 on community mobility using spatial time-series change o ...[more]

PMID: 32834269

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Project description:IntroductionThe safety profile of remdesivir, conditionally approved for COVID-19, was limited at its 2020 introduction. Adverse drug reactions (ADRs) for medicines are collected in VigiBase, the WHO Global Database of Individual Case Safety Reports (ICSRs).ObjectiveThis study aimed to provide a descriptive analysis of COVID-19 ICSR data focusing on remdesivir, including a disproportionality analysis (DA) of ADRs.MethodsA dedicated algorithm enabled retrieval of all COVID-19 treatment-specific ICSRs. A severity algorithm based on co-reported medicines and symptoms enabled selection of tocilizumab with its well established safety profile as comparator for remdesivir. Descriptive statistics were used for general ICSR demographics for all COVID-19-specific medicines, remdesivir and tocilizumab individually and furthermore to present treatment patterns of medicines co-reported with remdesivir. A COVID-19 indication-focused DA was deployed to minimize confounding from underlying polysymptomatic disease.Results14,574 COVID-19-related ICSRs were entered into VigiBase during 2020. Remdesivir was the most common medicine reported. Of 4944 remdesivir ICSRs, where tocilizumab was not co-reported, 93% described remdesivir as the sole suspect medicine. Sixty percent of ICSRs concerned males, median age was 63 years and the majority originated from the Americas (72%). In 1089 (21%) of remdesivir ICSRs, data indicated severe/critical disease. Co-reported medicines peaked during the first 3 days of remdesivir treatment. The DA for the established tocilizumab and the new remdesivir were mainly in line with the safety profiles for both medicines but suggested new safety concerns. The most reported ADRs for remdesivir represented liver dysfunction, kidney injury, death and bradycardia.ConclusionGlobal COVID-19-related ADR reporting proved useful in providing information on ADRs as well as on treatment patterns in this patient group. Indication-focused disproportionality analysis, together with the use of a comparator with a known safety profile, proved effective in identifying known safety information and suggested new safety concerns for remdesivir.

Project description:Coronavirus disease (COVID-19) spread across the globe through the human transmission. The World Health Organization suggested social distancing to curb the community spread. After national social lockdown started in India, air quality improved drastically. This further hypothesized to influence the environment and human health, and this study is positively the first to weigh it using multiple indices. The calculated environmental indices are photochemical ozone creation potential (POCP), acidification potential (AP), and eutrophication potential (EP). The cancer risk, chronic health index (CHI), and acute health index (AHI) were considered to calculate the health risk. The spatial trend change in the air pollution reflecting on these indices are calculated for four Indian megacities Delhi, Bangalore, Hyderabad, and Kolkata. Temporal variation was accounted for monthly (2019 vs 2020), one-week and two-weeks period during the social lockdown. The results showed a significant decrease in environmental and health risk during the lockdown due to a corresponding decrement in air pollution. The decrease in the particulate matter was found to play a vital role in altering the air pollution mediated risks of interest. Delhi showed a maximum difference in POCP and Acute HI by recording a dip of 70.79% and 43.53% respectively in 2020 during lockdown. The maximum reduction in health risk indices was 41%, 31%, 17%, 19% for Delhi, Bangalore, Hyderabad, and Kolkata. Bangalore recorded the maximum decline in EP, Cancer risk, Chronic HI by 66.66%, 58.62%, and 58.76% in 2020 compared to 2019. A maximum fall in AP was seen in Kolkata by 57.23% in 2020 among all cities. The connection between these drop-in indices and the cause of air pollutants were well discussed. This present paper gives more in-depth insights into air pollution's effect on environmental and health parameters by connecting and converging various air pollution aspects into a single scale. This study also enlightens the importance of controlling air pollution to have a better environment and healthy life to attain sustainable development.

Project description:ImportanceThe COVID-19 pandemic has posed a number of unprecedented challenges to the health care system in France, where hip fractures in the elderly population are a major public health concern.ObjectiveTo explore the association of the first nationwide COVID-19 lockdown in France with the absolute number of hip fractures among patients 50 years or older.Design, setting, and participantsThis retrospective cohort study used data from the French national hospitals database to identify patients 50 years or older who were hospitalized for hip fracture in France from January to July 2019 and January to July 2020.ExposuresThe first nationwide COVID-19 lockdown in France from March 16 to May 10, 2020.Main outcomes and measuresThe main outcome was the number of hospitalizations for hip fracture from January to July 2020 (study period) compared with the number of hospitalizations for hip fracture during the same period in 2019 (control period). Hospitalization rate ratios (HRRs) comparing the study period with the control period were calculated for 3 intervals (before lockdown [January 1 to March 15], during lockdown [March 16 to May 10], and after lockdown [May 11 to July 31]) and were stratified by gender, age and hospital type.ResultsThe study included 46 393 patients hospitalized for hip fracture during January to July 2019 (34 589 [74.4%] women; mean [SD] age, 82.8 [10.5] years) and 44 767 patients hospitalized for hip fracture from January to July 2020 (33 160 [74.1%] women; mean [SD] age, 82.9 [10.5] years). During the lockdown in 2020, 10 429 patients (23.30%) were hospitalized for hip fracture compared with 11 782 patients (25.40%) during the same period in 2019 (HRR, 0.89; 95% CI, 0.86-0.91; P < .001). The lockdown period was associated with a decrease in the number of hip fractures of 11% among women (from 8756 in 2019 to 7788 in 2020) and 13% among men (from 3026 in 2019 to 2641 in 2020). When the absolute number of hip fractures was stratified by age group, the lockdown period was associated with a decrease in the number of hip fractures in all age groups except in patients older than 89 years (HRR, 0.97; 95% CI, 0.92-1.01; P = .17). In the group of patients aged 80 to 89 years, the number of hip fractures decreased from 4925 to 4370 (HRR, 0.89; 95% CI, 0.85-0.92; P < .001). During the lockdown, hospitalizations decreased by 33% (HRR, 0.67; 95% CI, 0.63-0.71; P < .001) in public university hospitals and by 24% (HRR, 0.76; 95% CI, 0.73-0.79; P < .001) in public general hospitals but increased by 46% (HRR, 1.46; 95% CI,1.38-1.54; P < .001) in private for-profit hospitals.Conclusions and relevanceIn this cohort study, hospitalizations for hip fractures in France decreased by 11% during the first nationwide COVID-19 lockdown. Further studies are needed to investigate the long-lasting consequences of the COVID-19 pandemic on the incidence of osteoporotic fractures.

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Lockdown for COVID-19 and its impact on community mobility in India: An analysis of the COVID-19 Community Mobility Reports, 2020.

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Lockdown for COVID-19 and its impact on community mobility in India: An analysis of the COVID-19 Community Mobility Reports, 2020.

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