Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice.
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ABSTRACT:
SUBMITTER: Roth AN
PROVIDER: S-EPMC7289885 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Norovirus infection causes acute self-resolving diarrhea in wild-type neonatal mice.
Roth Alexa N AN Helm Emily W EW Mirabelli Carmen C Kirsche Erin E Smith Jonathan C JC Eurell Laura B LB Ghosh Sourish S Altan-Bonnet Nihal N Wobus Christiane E CE Karst Stephanie M SM
Nature communications 20200611 1
Human noroviruses are the leading cause of severe childhood diarrhea worldwide, yet we know little about their pathogenic mechanisms. Murine noroviruses cause diarrhea in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence in the translatability of findings to human norovirus disease. Herein we report that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice, thus mirroring t ...[more]
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