Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC7290025 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Wang Shengqi S Wang Neng N Zheng Yifeng Y Yang Bowen B Liu Pengxi P Zhang Fengxue F Li Min M Song Juxian J Chang Xu X Wang Zhiyu Z
Cell death & disease 20200611 6
Breast cancer stem cells (BCSCs) are considered to be the root of breast cancer occurrence and progression. However, the characteristics and regulatory mechanisms of BCSCs metabolism have been poorly revealed, which hinders the development of metabolism-targeted treatment strategies for BCSCs elimination. Herein, we demonstrated that the downregulation of Caveolin-1 (Cav-1) usually occurred in BCSCs and was associated with a metabolic switch from mitochondrial respiration to aerobic glycolysis. ...[more]