Single nucleotide polymorphisms in telomere length-related genes are associated with hepatocellular carcinoma risk in the Chinese Han population.

ABSTRACT: Background:Single nucleotide polymorphisms (SNPs) in telomere-related genes are associated with a high risk of hepatocellular carcinoma (HCC). In this study, we investigated the SNPs of telomere length-related genes and their correlation with HCC risk in the Chinese Han population. Materials and methods:A total of 473 HCC patients and 564 healthy volunteers were recruited. Overall, 42 SNPs distributed in telomere-related genes were selected and identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results:We found rs6713088 (OR?=?1.27, 95% CI?=?1.07-1.52, p?=?0.007), rs843711 (OR?=?1.29, 95% CI?=?1.09-1.54, p?=?0.004) and rs843706 (OR?=?1.30, 95% CI?=?1.09-1.55, p?=?0.003) in the ACYP2 gene, rs10936599 (OR?=?1.21, 95% CI?=?1.02-1.44, p?=?0.032) in the TERC gene and rs7708392 (OR?=?1.24, 95% CI?=?1.00-1.52, p?=?0.042) in the TNIP1 gene were associated with high HCC risk (OR?>?1). In contrast, rs1682111 (OR?=?0.77, 95% CI?=?0.64-0.94, p?=?0.008) in the ACYP2 gene, rs2320615 (OR?=?0.79, 95% CI?=?0.64-0.99, p?=?0.038) in the NAF1 gene, rs10069690 (OR?=?0.75, 95% CI?=?0.59-0.96, p?=?0.021) and rs2242652 (OR?=?0.70, 95% CI?=?0.55-0.90, p?=?0.004) in the TERT gene were associated with low HCC risk (OR?

SUBMITTER: Huang P 

PROVIDER: S-EPMC7290267 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature