Ontology highlight
ABSTRACT:
SUBMITTER: Tsurubuchi T
PROVIDER: S-EPMC7290312 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Tsurubuchi Takao T Shirakawa Makoto M Kurosawa Wataru W Matsumoto Kayo K Ubagai Risa R Umishio Hiroshi H Suga Yasuyo Y Yamazaki Junko J Arakawa Akihiro A Maruyama Yutaka Y Seki Takuya T Shibui Yusuke Y Yoshida Fumiyo F Zaboronok Alexander A Suzuki Minoru M Sakurai Yoshinori Y Tanaka Hiroki H Nakai Kei K Ishikawa Eiichi E Matsumura Akira A
Cells 20200521 5
Boron neutron capture therapy (BNCT) is a unique anticancer technology that has demonstrated its efficacy in numerous phase I/II clinical trials with boronophenylalanine (BPA) and sodium borocaptate (BSH) used as <sup>10</sup>B delivery agents. However, continuous drug administration at high concentrations is needed to maintain sufficient <sup>10</sup>B concentration within tumors. To address the issue of <sup>10</sup>B accumulation and retention in tumor tissue, we developed MMT1242, a novel bo ...[more]