Ontology highlight
ABSTRACT:
SUBMITTER: Colarusso A
PROVIDER: S-EPMC7290510 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Colarusso Andrea A Maroccia Zaira Z Parrilli Ermenegilda E Germinario Elena Angela Pia EAP Fortuna Andrea A Loizzo Stefano S Ricceri Laura L Tutino Maria Luisa ML Fiorentini Carla C Fabbri Alessia A
Toxins 20200504 5
Among gliomas, primary tumors originating from glial cells, glioblastoma (GBM) identified as WHO grade IV glioma, is the most common and aggressive malignant brain tumor. We have previously shown that the <i>Escherichia coli</i> protein toxin cytotoxic necrotizing factor 1 (CNF1) is remarkably effective as an anti-neoplastic agent in a mouse model of glioma, reducing the tumor volume, increasing survival, and maintaining the functional properties of peritumoral neurons. However, being unable to ...[more]