Ontology highlight
ABSTRACT:
SUBMITTER: Dumetier B
PROVIDER: S-EPMC7290580 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Dumétier Baptiste B Zadoroznyj Aymeric A Dubrez Laurence L
Cells 20200430 5
Over the last decade, the E3-ubiquitine ligases from IAP (Inhibitor of Apoptosis) family have emerged as potent regulators of immune response. In immune cells, they control signaling pathways driving differentiation and inflammation in response to stimulation of tumor necrosis factor receptor (TNFR) family, pattern-recognition receptors (PRRs), and some cytokine receptors. They are able to control the activity, the cellular fate, or the stability of actors of signaling pathways, acting at differ ...[more]