Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD.
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ABSTRACT:
SUBMITTER: Nashine S
PROVIDER: S-EPMC7290668 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD.
Nashine Sonali S Kenney M Cristina MC
Cells 20200429 5
Substantive evidence demonstrates the contribution of mitochondrial dysfunction in the etiology and pathogenesis of Age-related Macular Degeneration (AMD). Recently, extensive characterization of Mitochondrial‑Derived Peptides (MDPs) has revealed their cytoprotective role in several diseases, including AMD. Here we summarize the varied effects of MDPs on cellular and mitochondrial health, which establish the merit of MDPs as therapeutic targets for AMD. We argue that further research to delve in ...[more]
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