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Diagnostic Utility and Pathogenic Role of Circulating MicroRNAs in Vasospastic Angina.


ABSTRACT: We investigated the diagnostic value and pathophysiological role of circulating microRNA (miR) in vasospastic angina (VA). We enrolled patients who underwent coronary angiography for chest pain to explore the miR's diagnostic utility. In addition, we investigated the role of miRs in regulating endothelial nitric oxide synthase (eNOS) expression in human coronary artery endothelial cells (hCAECs). Among the 121 patients, 46 were diagnosed with VA (VA group), 26 with insignificant coronary lesions (ICL group), and 49 with atherothrombotic angina (AA group). The VA group showed a significantly higher expression of miR-17-5p, miR-92a-3p, and miR-126-3p than the ICL group. In contrast, miR-221-3p and miR-222-3p were upregulated in the AA group compared to the VA group, and all levels of miR-17-5p, miR-92a-3p, miR-126-3p, miR-145-5p, miR-221-3p, and miR-222-3p differed between the AA group and the ICL group. In the hCAECs, transfection with mimics (pre-miR) of miR-17-5p, miR-92a-3p, and miR-126-3p was associated with eNOS suppression. Additionally, transfection with inhibitors (anti-miR) of miR-92a-3p significantly rescued the eNOS suppression induced by lipopolysaccharide. In conclusion, the circulating miRs not only proved to have diagnostic utility, but also contributed to pathogenesis by eNOS regulation.

SUBMITTER: Park CS 

PROVIDER: S-EPMC7290712 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Diagnostic Utility and Pathogenic Role of Circulating MicroRNAs in Vasospastic Angina.

Park Chan Soon CS   Kim Inho I   Oh Gyu Chul GC   Han Jung-Kyu JK   Yang Han-Mo HM   Park Kyung Woo KW   Cho Hyun-Jai HJ   Kang Hyun-Jae HJ   Koo Bon-Kwon BK   Chung Woo-Young WY   Oh Seil S   Lee Hae-Young HY  

Journal of clinical medicine 20200502 5


We investigated the diagnostic value and pathophysiological role of circulating microRNA (miR) in vasospastic angina (VA). We enrolled patients who underwent coronary angiography for chest pain to explore the miR's diagnostic utility. In addition, we investigated the role of miRs in regulating endothelial nitric oxide synthase (eNOS) expression in human coronary artery endothelial cells (hCAECs). Among the 121 patients, 46 were diagnosed with VA (VA group), 26 with insignificant coronary lesions  ...[more]

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