Ontology highlight
ABSTRACT:
SUBMITTER: Azzalin A
PROVIDER: S-EPMC7290719 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Azzalin Alberto A Brambilla Francesca F Arbustini Eloisa E Basello Katia K Speciani Attilio A Mauri Pierluigi P Bezzi Paola P Magrassi Lorenzo L
Cells 20200518 5
Adaptation of glioblastoma to caloric restriction induces compensatory changes in tumor metabolism that are incompletely known. Here we show that in human glioblastoma cells maintained in exhausted medium, SHC adaptor protein 3 (SHC3) increases due to down-regulation of SHC3 protein degradation. This effect is reversed by glucose addition and is not present in normal astrocytes. Increased SHC3 levels are associated to increased glucose uptake mediated by changes in membrane trafficking of glucos ...[more]