Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review.
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ABSTRACT:
SUBMITTER: Onoi K
PROVIDER: S-EPMC7290914 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Immune Checkpoint Inhibitors for Lung Cancer Treatment: A Review.
Onoi Keisuke K Chihara Yusuke Y Uchino Junji J Shimamoto Takayuki T Morimoto Yoshie Y Iwasaku Masahiro M Kaneko Yoshiko Y Yamada Tadaaki T Takayama Koichi K
Journal of clinical medicine 20200506 5
The treatment of lung cancer has changed drastically in recent years owing to the advent of immune checkpoint inhibitors (ICIs). A 1992 study reported that programmed cell death-1 (PD-1), an immune checkpoint molecule, is upregulated during the induction of T cell death. Since then, various immunoregulatory mechanisms involving PD-1 have been clarified, and the successful use of PD-1 blockers in anticancer therapy eventually led to the development of the current generation of ICIs. Nivolumab was ...[more]
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