Ontology highlight
ABSTRACT:
SUBMITTER: Hazeslip L
PROVIDER: S-EPMC7290933 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Hazeslip Lindsey L Zafar Maroof Khan MK Chauhan Muhammad Zain MZ Byrd Alicia K AK
Genes 20200521 5
DNA Helicase B (HELB) is a conserved helicase in higher eukaryotes with roles in the initiation of DNA replication and in the DNA damage and replication stress responses. HELB is a predominately nuclear protein in G<sub>1</sub> phase where it is involved in initiation of DNA replication through interactions with DNA topoisomerase 2-binding protein 1 (TOPBP1), cell division control protein 45 (CDC45), and DNA polymerase α-primase. HELB also inhibits homologous recombination by reducing long-range ...[more]