Mortality after Delay of Adequate Empiric Antimicrobial Treatment of Bloodstream Infection.

ABSTRACT: Timely empiric antimicrobial therapy is one of the cornerstones of the management of suspected bloodstream infection (BSI). However, studies about the effects of empiric therapy on mortality have reported inconsistent results. The objective of this study was to estimate the effect of delay of appropriate empiric therapy on early mortality in patients with BSI. Methods: Data for the propensity score matching (PSM) study were obtained from a cohort of patients with BSI. Inadequate empiric treatment was defined as in vitro resistance to the antimicrobial regimen administered <6 h after blood cultures were taken. The primary outcome measure was 14-day mortality. Thirty-day mortality and median length of stay (LOS) were secondary outcomes. PSM was applied to control for confounding. Results: Of

SUBMITTER: Lambregts MMC 

PROVIDER: S-EPMC7290963 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature