Pathogenic Biohacking: Induction, Modulation and Subversion of Host Transcriptional Responses by Listeria monocytogenes.
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ABSTRACT:
SUBMITTER: Eldridge MJG
PROVIDER: S-EPMC7290974 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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Pathogenic Biohacking: Induction, Modulation and Subversion of Host Transcriptional Responses by Listeria monocytogenes.
Eldridge Matthew J G MJG Cossart Pascale P Hamon Mélanie A MA
Toxins 20200505 5
During infection, the foodborne bacterial pathogen Listeria monocytogenes dynamically influences the gene expression profile of host cells. Infection-induced transcriptional changes are a typical feature of the host-response to bacteria and contribute to the activation of protective genes such as inflammatory cytokines. However, by using specialized virulence factors, bacterial pathogens can target signaling pathways, transcription factors, and epigenetic mechanisms to alter host gene expression ...[more]
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