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MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy.


ABSTRACT: Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.

SUBMITTER: Rodriquenz MG 

PROVIDER: S-EPMC7291039 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy.

Rodriquenz Maria Grazia MG   Roviello Giandomenico G   D'Angelo Alberto A   Lavacchi Daniele D   Roviello Franco F   Polom Karol K  

Journal of clinical medicine 20200511 5


Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review  ...[more]

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