Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy.
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ABSTRACT:
SUBMITTER: Le Roux LG
PROVIDER: S-EPMC7291064 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Axonal Transport as an In Vivo Biomarker for Retinal Neuropathy.
Le Roux Lucia G LG Qiu Xudong X Jacobsen Megan C MC Pagel Mark D MD Gammon Seth T ST Piwnica-Worms David R DR Schellingerhout Dawid D
Cells 20200522 5
We illuminate a possible explanatory pathophysiologic mechanism for retinal cellular neuropathy by means of a novel diagnostic method using ophthalmoscopic imaging and a molecular imaging agent targeted to fast axonal transport. The retinal neuropathies are a group of diseases with damage to retinal neural elements. Retinopathies lead to blindness but are typically diagnosed late, when substantial neuronal loss and vision loss have already occurred. We devised a fluorescent imaging agent based o ...[more]
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