Ontology highlight
ABSTRACT:
SUBMITTER: D'Aguanno S
PROVIDER: S-EPMC7291206 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
D'Aguanno Simona S Del Bufalo Donatella D
Cells 20200521 5
The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is responsible for a cell's fate. Due to the recognized relevance of this family in cancer progression and response to therapy, different efforts have made in recent years in order to develop small molecules able to target anti-apoptotic proteins such as Bcl-2, Bcl-xL and Mcl-1. The limitations of the first Bcl-2 family targeted drugs, regarding on-target and off-target toxicities, have been overcome with the developm ...[more]