Spatio-Temporal Roles of ASD-Associated Variants in Human Brain Development.
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ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC7291218 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Spatio-Temporal Roles of ASD-Associated Variants in Human Brain Development.
Genes 20200511 5
Transcriptional regulation of the genome arguably provides the basis for the anatomical elaboration and dynamic operation of the human brain. It logically follows that genetic variations affecting gene transcription contribute to mental health disorders, including autism spectrum disorder (ASD). A number of recent studies have shown the role of <i>de novo</i> variants (DNVs) in disrupting early neurodevelopment. However, there is limited knowledge concerning the role of inherited variants during ...[more]
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