Ontology highlight
ABSTRACT:
SUBMITTER: Wysocki T
PROVIDER: S-EPMC7291248 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Wysocki Tomasz T Olesińska Marzena M Paradowska-Gorycka Agnieszka A
Cells 20200502 5
Rheumatoid arthritis (RA) is an autoimmune disease with an unclear pathogenic mechanism. However, it has been proven that the key underlying risk factor is a genetic predisposition. Association studies of the HLA-DRB1 gene clearly indicate its importance in RA morbidity. This review presents the current state of knowledge on the impact of HLA-DRB1 gene, functioning both as a component of the patient's genome and as an environmental risk factor. The impact of known HLA-DRB1 risk variants on the s ...[more]