Ontology highlight
ABSTRACT:
SUBMITTER: Patterson EI
PROVIDER: S-EPMC7291308 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Patterson Edward I EI Khanipov Kamil K Swetnam Daniele M DM Walsdorf Samantha S Kautz Tiffany F TF Thangamani Saravanan S Fofanov Yuriy Y Forrester Naomi L NL
Viruses 20200515 5
Mutations are incorporated into the genomes of RNA viruses at an optimal frequency and altering this precise frequency has been proposed as a strategy to create live-attenuated vaccines. However, determining the effect of specific mutations that alter fidelity has been difficult because of the rapid selection of the virus population during replication. By deleting residues of the structural polyprotein PE2 cleavage site, E3D56-59, in Venezuelan equine encephalitis virus (VEEV) TC-83 vaccine stra ...[more]