Dataset Information

Case of caval lobular capillary hemangioma mimicking tumor thrombus.

ABSTRACT:

Introduction

We presented a rare case of caval lobular capillary hemangioma.

Case presentation

A 66-year-old female visited our department complaint with shadow defect in vena cava of right renal hilum appeared on computed tomography for periodically checking 3 years after radical hysterectomy with bilateral ovariectomy. Abdominal computed tomography identified a shadow defect of 35 mm in diameter in the inferior vena cava continuing posteriorly to a 35 mm mass of retroperitoneum. During the total removal of this lesion, we identified the lesion was connected to right ovarian vein. The specimen consisted of microcapillaries which formed reticular structure. Immunostaining of specimens identified positive CD31, CD34, and Factor 8 in all cells. Ki67 antibody was positive at 2-3% of all cells. These findings suggested the tumor was intravenous lobular papillary hemangioma.

Conclusion

This is the first report of intravenous lobular papillary hemangioma originated from right ovarian vein and extended to inferior vena cava.

SUBMITTER: Hashimoto S

PROVIDER: S-EPMC7292108 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Publications

Case of caval lobular capillary hemangioma mimicking tumor thrombus.

Hashimoto Sho S Obinata Daisuke D Yamaguchi Kenya K Sakurai Fuminori F Yoshida Toshiyuki T Yoshizawa Tsuyoshi T Matsui Tsuyoshi T Mochida Junichi J Masuda Shinobu S Takahashi Satoru S

IJU case reports 20190116 2

<h4>Introduction</h4>We presented a rare case of caval lobular capillary hemangioma.<h4>Case presentation</h4>A 66-year-old female visited our department complaint with shadow defect in vena cava of right renal hilum appeared on computed tomography for periodically checking 3 years after radical hysterectomy with bilateral ovariectomy. Abdominal computed tomography identified a shadow defect of 35 mm in diameter in the inferior vena cava continuing posteriorly to a 35 mm mass of retroperitoneum. ...[more]

PMID: 32743379

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Project description:ImportanceChoroidal hemangiomas are defined by a thickened choroid owing to vessel overgrowth, which may increase the intraocular pressure and lead to glaucoma. Choroidal hemangioma and glaucoma often co-occur in patients with Sturge-Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations.ObjectiveTo determine whether the mutation found in most capillary malformations, GNAQ R183Q (c.548G>A), was present in the choroidal hemangioma of a patient with Sturge-Weber syndrome.Design, setting, and participantUsing laser-capture microdissection, choroidal blood vessels were isolated from paraffin-embedded tissue sections, and genomic DNA was extracted for mutational analysis. Choroidal sections were analyzed in parallel. A patient with choroidal hemangioma and Sturge-Weber syndrome who had undergone enucleation was analyzed in this study at Boston Children's Hospital. Negative controls were choroidal tissue from an eye with retinoblastoma and unaffected lung tissue; brain tissue from a different patient with Sturge-Weber syndrome served as a positive control. Infantile hemangioma was analyzed as well. Data were analyzed in 2018.Main outcomes and measuresThe mutant allelic frequency of GNAQ R183 and GNAQ Q209L/H/P was determined by droplet digital polymerase chain reaction on isolated genomic DNA. The infantile hemangioma marker glucose transporter-1 was visualized by immunofluorescent staining of tissue sections.ResultsThe GNAQ R183Q mutation was present in the patient's choroidal vessels (21.1%) at a frequency similar to that found in brain tissue from a different patient with Sturge-Weber syndrome (25.1%). In contrast, choroidal vessels from a case of retinoblastoma were negative for the mutation (0.5%), as was lung tissue (0.2%). The patient's choroidal tissue was negative for the 3 GNAQ mutations associated with congenital hemangioma and for the infantile hemangioma marker glucose transporter-1.Conclusions and relevanceThe results suggest that a more accurate description for choroidal hemangioma in patients with Sturge-Weber syndrome is choroidal capillary malformation. This finding may explain why propranolol, used to treat infantile hemangiomas, has been largely ineffective in patients with choroidal hemangioma. Further studies are needed to corroborate this finding.

Dataset Information

Case of caval lobular capillary hemangioma mimicking tumor thrombus.

Introduction

Case presentation

Conclusion

Publications

Case of caval lobular capillary hemangioma mimicking tumor thrombus.

Similar Datasets

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