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Therapeutic effects of vitamin D on acetic acid-induced colitis in rats.


ABSTRACT: PURPOSE:To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model. METHODS:A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calcitriol 1 µg/kg for 5 days. RESULTS:Plasma tumor necrosis factor alpha, Pentraxin 3, and malondialdehyde levels were significantly lower in the calcitriol administered colitis group than in the standard colitis group (p<0.01). In the Calcitriol group, there was a significant histological improvement in hyperemia, hemorrhage and necrotic areas in the epithelium compared to the placebo group (p <0.000). CONCLUSION:The findings suggest that calcitriol may be an agent that could be used in acute colitis treatment.

SUBMITTER: Bademci R 

PROVIDER: S-EPMC7292621 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Therapeutic effects of vitamin D on acetic acid-induced colitis in rats.

Bademci Refik R   Erdoğan Mümin Alper MA   Kara Ali Yücel AY   Yiğittürk Gürkan G   Erbaş Oytun O   Erbaş Oytun O  

Acta cirurgica brasileira 20200605 4


<h4>Purpose</h4>To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model.<h4>Methods</h4>A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Group 1 was given 1 ml/kg 0.9% NaCl intraperitoneally; rats belonging to Group 2 were administered calci  ...[more]

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