Ontology highlight
ABSTRACT:
SUBMITTER: Wu J
PROVIDER: S-EPMC7292629 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Wu Jingxia J Weisshaar Nina N Hotz-Wagenblatt Agnes A Madi Alaa A Ma Sicong S Mieg Alessa A Hering Marvin M Mohr Kerstin K Schlimbach Tilo T Borgers Helena H Cui Guoliang G
Science advances 20200612 24
CD8<sup>+</sup> T cells become functionally impaired or "exhausted" in chronic infections, accompanied by unwanted body weight reduction and muscle mass loss. Whether muscle regulates T cell exhaustion remains incompletely understood. We report that mouse skeletal muscle increased interleukin (IL)-15 production during LCMV clone 13 chronic infection. Muscle-specific ablation of <i>Il15</i> enhanced the CD8<sup>+</sup> T cell exhaustion phenotype. Muscle-derived IL-15 was required to maintain a p ...[more]