Ontology highlight
ABSTRACT:
SUBMITTER: Lukowski AL
PROVIDER: S-EPMC7293229 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Lukowski April L AL Liu Jianxin J Bridwell-Rabb Jennifer J Narayan Alison R H ARH
Nature communications 20200612 1
Biocatalysts that perform C-H hydroxylation exhibit exceptional substrate specificity and site-selectivity, often through the use of high valent oxidants to activate these inert bonds. Rieske oxygenases are examples of enzymes with the ability to perform precise mono- or dioxygenation reactions on a variety of substrates. Understanding the structural features of Rieske oxygenases responsible for control over selectivity is essential to enable the development of this class of enzymes for biocatal ...[more]