Ontology highlight
ABSTRACT:
SUBMITTER: Sachdeva V
PROVIDER: S-EPMC7293598 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Sachdeva Vedant V Husain Kabir K Sheng Jiming J Wang Shenshen S Murugan Arvind A
Proceedings of the National Academy of Sciences of the United States of America 20200526 23
Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we demonstrate that environmental changes on an intermediate timescale can reliably evolve generalists, even when faster or slower environmental changes are unable to do so. We find th ...[more]