Ontology highlight
ABSTRACT:
SUBMITTER: Qiu K
PROVIDER: S-EPMC7293731 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Qiu Kaixin K Wang Shuai S Wang Xin X Wang Fengting F Wu Yili Y
BioMed research international 20200605
Amyloid-<i>β</i> protein (A<i>β</i>) is the main component of neuritic plaques, the pathological hallmark of Alzheimer's disease (AD). <i>β</i>-site APP cleaving enzyme 1 (BACE1) is a major <i>β</i>-secretase contributing to A<i>β</i> generation. <i>β</i>-site APP cleaving enzyme 2 (BACE2), the homolog of BACE1, is not only a <i>θ</i>-secretase but also a conditional <i>β</i>-secretase. Previous studies showed that regulator of calcineurin 1 (RCAN1) is markedly increased by AD and promotes BACE1 ...[more]