Ontology highlight
ABSTRACT:
SUBMITTER: Kaminski L
PROVIDER: S-EPMC7293888 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kaminski Lisa L Torrino Stéphanie S Dufies Maeva M Djabari Zied Z Haider Romain R Roustan François-René FR Jaune Emilie E Laurent Kathiane K Nottet Nicolas N Michiels Jean-François JF Gesson Maeva M Rocchi Stéphane S Mazure Nathalie M NM Durand Matthieu M Tanti Jean-François JF Ambrosetti Damien D Clavel Stephan S Ben-Sahra Issam I Bost Frédéric F
Cancer research 20190507 13
Although tumorigenesis is dependent on the reprogramming of cellular metabolism, the metabolic pathways engaged in the formation of metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) plays a pleiotropic role in the control of cancer cell metabolism and has been associated with a good prognosis in prostate cancer. Here, we show that PGC1α represses the metastatic properties of prostate cancer cells via mo ...[more]