E-cadherin deregulation in breast cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Corso G
PROVIDER: S-EPMC7294130 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
E-cadherin deregulation in breast cancer.
Corso Giovanni G Figueiredo Joana J De Angelis Simone Pietro SP Corso Federica F Girardi Antonia A Pereira Joana J Seruca Raquel R Bonanni Bernardo B Carneiro Patricia P Pravettoni Gabriella G Guerini Rocco Elena E Veronesi Paolo P Montagna Giacomo G Sacchini Virgilio V Gandini Sara S
Journal of cellular and molecular medicine 20200416 11
E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy. ...[more]
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