Ontology highlight
ABSTRACT:
SUBMITTER: Jung Y
PROVIDER: S-EPMC7294780 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Jung Yoonji Y Kwon Sujeong S Ham Seokjin S Lee Dongyeop D Park Hae-Eun H HH Yamaoka Yasuyo Y Jeong Dae-Eun DE Artan Murat M Altintas Ozlem O Park Sangsoon S Hwang Wooseon W Lee Yujin Y Son Heehwa G HG An Seon Woo A SWA Kim Eun Ji E EJE Seo Mihwa M Lee Seung-Jae V SV
Aging cell 20200531 6
Excessive glucose causes various diseases and decreases lifespan by altering metabolic processes, but underlying mechanisms remain incompletely understood. Here, we show that Lipin 1/LPIN-1, a phosphatidic acid phosphatase and a putative transcriptional coregulator, prevents life-shortening effects of dietary glucose on Caenorhabditis elegans. We found that depletion of lpin-1 decreased overall lipid levels, despite increasing the expression of genes that promote fat synthesis and desaturation, ...[more]