Plasmodium falciparum translational machinery condones polyadenosine repeats.
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ABSTRACT:
SUBMITTER: Pavlovic Djuranovic S
PROVIDER: S-EPMC7295572 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
<i>Plasmodium falciparum</i> translational machinery condones polyadenosine repeats.
Pavlovic Djuranovic Slavica S Erath Jessey J Andrews Ryan J RJ Bayguinov Peter O PO Chung Joyce J JJ Chalker Douglas L DL Fitzpatrick James Aj JA Moss Walter N WN Szczesny Pawel P Djuranovic Sergej S
eLife 20200529
<i>Plasmodium falciparum</i> is a causative agent of human malaria. Sixty percent of mRNAs from its extremely AT-rich (81%) genome harbor long polyadenosine (polyA) runs within their ORFs, distinguishing the parasite from its hosts and other sequenced organisms. Recent studies indicate polyA runs cause ribosome stalling and frameshifting, triggering mRNA surveillance pathways and attenuating protein synthesis. Here, we show that <i>P. falciparum</i> is an exception to this rule. We demonstrate t ...[more]
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