Ontology highlight
ABSTRACT:
SUBMITTER: Lamas-Toranzo I
PROVIDER: S-EPMC7295574 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
eLife 20200602
The fusion of gamete membranes during fertilization is an essential process for sexual reproduction. Despite its importance, only three proteins are known to be indispensable for sperm-egg membrane fusion: the sperm proteins IZUMO1 and SPACA6, and the egg protein JUNO. Here we demonstrate that another sperm protein, TMEM95, is necessary for sperm-egg interaction. TMEM95 ablation in mice caused complete male-specific infertility. Sperm lacking this protein were morphologically normal exhibited no ...[more]