Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis.
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ABSTRACT:
SUBMITTER: Marchant C
PROVIDER: S-EPMC7295590 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis.
Marchant Ceilidh C Anderson Peter P Schwarz Quenten Q Wiszniak Sophie S
Development (Cambridge, England) 20200611 11
Craniofacial development is a complex morphogenic process that requires highly orchestrated interactions between multiple cell types. Blood vessel-derived angiocrine factors are known to promote proliferation of chondrocytes in Meckel's cartilage to drive jaw outgrowth, however the specific factors controlling this process remain unknown. Here, we use <i>in vitro</i> and <i>ex vivo</i> cell and tissue culture, as well as genetic mouse models, to identify IGF1 as a novel angiocrine factor directi ...[more]
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