Ontology highlight
ABSTRACT:
SUBMITTER: Chang Z
PROVIDER: S-EPMC7295784 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Chang Zhenyu Z Zhang Yanan Y Liu Jie J Zheng Yiqiong Y Li Huayue H Kong Yanjun Y Li Pengyun P Peng Haiwen H Shi Yajiao Y Cao Bo B Ran Fang F Chen Yingjie Y Song Yuhua Y Ye Qinong Q Ding Lihua L
Cell death & disease 20200615 6
A further understanding of tumor angiogenesis is urgently needed due to the limited therapeutic efficacy of anti-angiogenesis agents. However, the origin of endothelial cells (EC) in tumors remains widely elusive and controversial. Snail has been thoroughly elucidated as a master regulator of the epithelial-mesenchymal transition (EMT), but its role in endothelium generation is not yet established. In this study, we reported a new and unexpected function of Snail in endothelium generation by bre ...[more]