Role of PI3K/AKT pathway in cancer: the framework of malignant behavior.
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ABSTRACT:
SUBMITTER: Jiang N
PROVIDER: S-EPMC7295848 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Role of PI3K/AKT pathway in cancer: the framework of malignant behavior.
Jiang Ningni N Dai Qijie Q Su Xiaorui X Fu Jianjiang J Feng Xuancheng X Peng Juan J
Molecular biology reports 20200424 6
Given that the PI3K/AKT pathway has manifested its compelling influence on multiple cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in various human cancers. We state the abnormalities of PI3K/AKT pathway in different cancers, which are closely related with tumorigenesis, proliferation, growth, apoptosis, invasion, metastasis, epithelial-mesenchymal transition, stem-like phenotype, immune microenvironment and drug resistance of cancer cells. In addition, we i ...[more]
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