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Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.


ABSTRACT: Family history of breast and related cancers can indicate increased breast cancer (BC) risk. In national familial breast cancer (FBC) guidelines, the risk is stratified to guide referral decisions. We aimed to identify characteristics associated with the recommendation for referral in a large cohort of women undergoing FBC risk assessment in a recent primary care study. Demographic, family history, psychological and behavioural factors were collected with family history questionnaires, psychological questionnaires and manual data extraction from general practice electronic health records. Participants were women aged 30-60 with no previous history of breast or ovarian cancer. Data from 1127 women were analysed with stepwise logistic regression. Two multivariable logistic models were developed to predict recommendations for referral: using the entire cohort (n?=?1127) and in a subgroup with uncertain risks (n?=?168). Model performance was assessed by the area under the receiver operating curve (AUC). In all 1127 women, a multivariable model incorporating five family history components (BC aged

SUBMITTER: Lee SI 

PROVIDER: S-EPMC7295867 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Characteristics predicting recommendation for familial breast cancer referral in a cohort of women from primary care.

Lee Siang Ing SI   Qureshi Nadeem N   Dutton Brittany B   Kai Joe J   Weng Stephen S  

Journal of community genetics 20200122 3


Family history of breast and related cancers can indicate increased breast cancer (BC) risk. In national familial breast cancer (FBC) guidelines, the risk is stratified to guide referral decisions. We aimed to identify characteristics associated with the recommendation for referral in a large cohort of women undergoing FBC risk assessment in a recent primary care study. Demographic, family history, psychological and behavioural factors were collected with family history questionnaires, psycholog  ...[more]

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