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The effect of exenatide on fasting bile acids in newly diagnosed type 2 diabetes mellitus patients, a pilot study.

ABSTRACT: BACKGROUND:Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) demonstrated good glycemic efficacy in patients with type 2 diabetes mellitus (T2DM) recent years, whereas studies on GLP-1 RAs' biliary effects were limited. Therefore, we aimed to assess the effect of exenatide on bile acids (BAs) and investigate the role of BAs in the glycemic control effect of exenatide. METHODS:Thirty-eight newly diagnosed T2DM participants without glucose-lowering drugs intake were recruited. Plasma total bile acids in fasting state (FTBAs) and other parameters were tested at baseline. Then exenatide were applied to the T2DM participants for 12?weeks. FTBAs and glycemic parameters were measured again after exenatide treatment, and correlation analysis between changes of FTBAs and glycemic parameters were conducted to investigate the role of BAs in the glycemic control effect of exenatide. RESULTS:The baseline FTBAs level of T2DM patients had no significance (3.84?±?2.06 vs. 3.87?±?2.89, P?=?0.954) compared with healthy subjects. After 12-week exenatide treatment for the T2DM patients, FTBAs were decreased from 3.84?±?2.06??mol/L to 3.06?±?1.27??mol/L (P?

SUBMITTER: Li B

PROVIDER: S-EPMC7296654 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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The effect of exenatide on fasting bile acids in newly diagnosed type 2 diabetes mellitus patients, a pilot study.

Li Boyu B Hu Yanjin Y Wang Guang G Liu Lihong L

BMC pharmacology & toxicology 20200615 1

<h4>Background</h4>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) demonstrated good glycemic efficacy in patients with type 2 diabetes mellitus (T2DM) recent years, whereas studies on GLP-1 RAs' biliary effects were limited. Therefore, we aimed to assess the effect of exenatide on bile acids (BAs) and investigate the role of BAs in the glycemic control effect of exenatide.<h4>Methods</h4>Thirty-eight newly diagnosed T2DM participants without glucose-lowering drugs intake were recruited. P ...[more]

PMID: 32539783

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The effect of exenatide on fasting bile acids in newly diagnosed type 2 diabetes mellitus patients, a pilot study.

Publications

The effect of exenatide on fasting bile acids in newly diagnosed type 2 diabetes mellitus patients, a pilot study.

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