Dataset Information

Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study.

ABSTRACT:

Backgrounds

The role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the associations between (pre)diabetes and RV and RA structure and function, and whether these are mediated by left ventricular (LV) alterations or pulmonary pressure.

Methods

Participants of the Maastricht Study; a population-based cohort study (426 normal glucose metabolism (NGM), 142 prediabetes, 224 diabetes), underwent two-dimensional and tissue Doppler echocardiography. Multiple linear regression analyses with pairwise comparisons of (pre)diabetes versus NGM, adjusted for cardiovascular risk factors, and mediation analyses were used.

Results

In general, differences were small. Nevertheless, in individuals with prediabetes and diabetes compared to NGM; RA volume index was lower (both p?trend?trend?trend?=?0.04), TDI S'RV was lower (p?=?0.08 and p?trend?trend?=?0.01) and TDI A'RV was lower (p?trend?=?0.04). Only the differences in RA volume index (7.8%) and RV diameter (6.2%) were mediated by the maximum tricuspid gradient, but no other LV structure and function measurements.

Conclusions

(Pre)diabetes is associated with structural RA and RV changes, and impaired RV systolic and diastolic function, independent of cardiovascular risk factors. These associations were largely not mediated by indices of LV structure, LV function or pulmonary pressure. This suggests that (pre)diabetes affects RA and RV structure and function due to direct myocardial involvement.

SUBMITTER: Linssen PBC

PROVIDER: S-EPMC7296751 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study.

Linssen Pauline B C PBC Veugen Marja G J MGJ Henry Ronald M A RMA van der Kallen Carla J H CJH Kroon Abraham A AA Schram Miranda T MT Brunner-La Rocca Hans-Peter HP Stehouwer Coen D A CDA

Cardiovascular diabetology 20200615 1

<h4>Backgrounds</h4>The role of right ventricular (RV) and atrial (RA) structure and function, in the increased heart failure risk in (pre)diabetes is incompletely understood. The purpose of this study is to investigate the associations between (pre)diabetes and RV and RA structure and function, and whether these are mediated by left ventricular (LV) alterations or pulmonary pressure.<h4>Methods</h4>Participants of the Maastricht Study; a population-based cohort study (426 normal glucose metabol ...[more]

PMID: 32539792

Similar Datasets

Project description:ObjectiveThe knowledge regarding maternal cardiovascular hemodynamic adaptation in twin pregnancies is incomplete. We performed a longitudinal investigation of maternal right ventricular (RV) and left atrial (LA) function in a cohort of uncomplicated twin pregnancies compared to singleton pregnancies.Study designHealthy women with uncomplicated twin pregnancies were prospectively enrolled and assessed by transthoracic echocardiography at 10-15 weeks' (w) gestation (T1), 19-26 w gestation (T2), and 30-38 w gestation (T3). Subjects with uneventful singleton pregnancies were selected as controls at the same gestational ages. Cardiac findings were compared to those of women with uneventful singleton gestations. RV systolic and diastolic functions were assessed by conventional echocardiography (FAC, TAPSE, sPAP, E, A, DT) and tissue Doppler imaging (TDI) (E', A', S', IVA, IVCT, IVRT, ET, MPI), and LA dimensions were calculated. Speckle-tracking imaging was also applied to evaluate RV global longitudinal strain and LA 2D strains (at LV end-systole (LAS) and at atrial contraction (LAA)).ResultsOverall, 30 uncomplicated twin and 30 uncomplicated singleton pregnancies were included. Regarding maternal RV function in twins, all the parameters (FAC, TAPSE, sPAP, E, A, E/A, DT, E/E', IVA, IVCT, MPI and 2D longitudinal strain) were almost stable throughout gestation, with the exception of the TDI findings (E' decreased from T1 to T3 (p = 0.03), while E'/A' increased from T1 to T2 and then decreased (p = 0.01); A' and basal S' increased (p = 0.04 and p = 0.03, respectively), while IVRT and ET significantly decreased (p = 0.009 and p = 0.007, respectively)). These findings were similar to those found for singleton pregnancies. LA dimensions significantly increased throughout gestation in both twins and singletons (p < 0.001), without intergroup difference. LA strains did not vary during either twin or singleton pregnancies, except for LAA in T1, which was higher among twins than among singletons.ConclusionMaternal RV and LA function in uncomplicated twin pregnancies does not seem to undergo more significant changes than in singletons, being characterized by similar findings in RV systolic and diastolic functions, as well as LA dimensions and strains.

Dataset Information

Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study.

Backgrounds

Methods

Results

Conclusions

Publications

Associations of (pre)diabetes with right ventricular and atrial structure and function: the Maastricht Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets