Ontology highlight
ABSTRACT:
SUBMITTER: Xu Z
PROVIDER: S-EPMC7296778 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Xu Zhen Z Takizawa Fumio F Casadei Elisa E Shibasaki Yasuhiro Y Ding Yang Y Sauters Thomas J C TJC Yu Yongyao Y Salinas Irene I Sunyer J Oriol JO
Science immunology 20200201 44
Although mammalian secretory immunoglobulin A (sIgA) targets mucosal pathogens for elimination, its interaction with the microbiota also enables commensal colonization and homeostasis. This paradoxical requirement in the control of pathogens versus microbiota raised the question of whether mucosal (secretory) Igs (sIgs) evolved primarily to protect mucosal surfaces from pathogens or to maintain microbiome homeostasis. To address this central question, we used a primitive vertebrate species (rain ...[more]