Neurofibrillary Tangles and Conversion to Mild Cognitive Impairment with Certain Antihypertensives.

ABSTRACT: BACKGROUND:Individuals taking renin angiotensin system (RAS) acting antihypertensives exhibit slower cognitive decline and are less likely to progress from mild cognitive impairment (MCI) to Alzheimer's disease (AD), but the mechanism remains unclear. OBJECTIVE:We tested the hypothesis that individuals taking RAS acting antihypertensives exhibit less AD-related neuropathology and slower disease progression than individuals taking non-RAS acting antihypertensives. METHOD:Participants included 83 individuals with MCI who were taking an antihypertensive at baseline, had at least two follow-up visits, and had postmortem neuropathological data. Participants were old (M?=?83.1 years), 32% male, well educated (M?=?15.7 years), and 9.2% Black. RESULTS:RAS medication users (N?=?38) were less likely to progress to AD than non-RAS users (N?=?45). RAS users exhibited fewer neurofibrillary tangles than non-RAS users in the hippocampal CA1 region (p?

SUBMITTER: Wharton W 

PROVIDER: S-EPMC7297195 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature