Ontology highlight
ABSTRACT:
SUBMITTER: Colpitts CC
PROVIDER: S-EPMC7297535 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Colpitts Che C CC Ridewood Sophie S Schneiderman Bethany B Warne Justin J Tabata Keisuke K Ng Caitlin F CF Bartenschlager Ralf R Selwood David L DL Towers Greg J GJ
eLife 20200616
Counteracting innate immunity is essential for successful viral replication. Host cyclophilins (Cyps) have been implicated in viral evasion of host antiviral responses, although the mechanisms are still unclear. Here, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). Pharmacological inhibition of CypA rescues PKR from antagonism by HCV NS5A, leading to activation of an interferon regulatory f ...[more]