Ontology highlight
ABSTRACT:
SUBMITTER: Vondrova L
PROVIDER: S-EPMC7297730 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Vondrova Lucie L Kolesar Peter P Adamus Marek M Nociar Matej M Oliver Antony W AW Palecek Jan J JJ
Scientific reports 20200616 1
The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting (HAWK or KITE) subunits. Mutual interactions of these subunits constitute the basal architecture of the SMC complexes. In addition, binding of ATP molecules to the SMC subunits and their hydrolysis drive dynamics of these complexes. Here, we developed new systems to follow the interactions between SMC5/6 subunits and the relative stability of the complex. First, we show that the ...[more]