Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
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ABSTRACT:
SUBMITTER: Zhang Z
PROVIDER: S-EPMC7298042 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Hepatic HuR modulates lipid homeostasis in response to high-fat diet.
Zhang Zhuojun Z Zong Chen C Jiang Mingyang M Hu Han H Cheng Xiaolei X Ni Juhua J Yi Xia X Jiang Bin B Tian Feng F Chang Ming-Wen MW Su Wen W Zhu Lijun L Li Jinfan J Xiang Xueping X Miao Congxiu C Gorospe Myriam M de Cabo Rafael R de Cabo Rafael R Dou Yali Y Ju Zhenyu Z Ju Zhenyu Z Yang Jichun J Jiang Changtao C Yang Zhongzhou Z Wang Wengong W
Nature communications 20200616 1
Lipid transport and ATP synthesis are critical for the progression of non-alcoholic fatty liver disease (NAFLD), but the underlying mechanisms are largely unknown. Here, we report that the RNA-binding protein HuR (ELAVL1) forms complexes with NAFLD-relevant transcripts. It associates with intron 24 of Apob pre-mRNA, with the 3'UTR of Uqcrb, and with the 5'UTR of Ndufb6 mRNA, thereby regulating the splicing of Apob mRNA and the translation of UQCRB and NDUFB6. Hepatocyte-specific HuR knockout red ...[more]
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