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A comprehensive map of disease networks and molecular drug discoveries for glaucoma.


ABSTRACT: Glaucoma is the leading cause of irreversible blindness worldwide. The molecular etiology of glaucoma is complex and unclear. At present, there are few drugs available for glaucoma treatment. The aim of the present study was to perform a systematic analysis of glaucoma candidate drugs/chemicals based on glaucoma genes, including genetic factors and differentially expressed (DE) genes. In total, 401 genes from the genetic databases and 1656 genes from the DE gene analysis were included in further analyses. In terms of glaucoma-related genetic factors, 54 pathways were significantly enriched (FDR?

SUBMITTER: Wang H 

PROVIDER: S-EPMC7298047 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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A comprehensive map of disease networks and molecular drug discoveries for glaucoma.

Wang Haixin H   Deng Yanhui Y   Wan Ling L   Huang Lulin L  

Scientific reports 20200616 1


Glaucoma is the leading cause of irreversible blindness worldwide. The molecular etiology of glaucoma is complex and unclear. At present, there are few drugs available for glaucoma treatment. The aim of the present study was to perform a systematic analysis of glaucoma candidate drugs/chemicals based on glaucoma genes, including genetic factors and differentially expressed (DE) genes. In total, 401 genes from the genetic databases and 1656 genes from the DE gene analysis were included in further  ...[more]

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