Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study.

ABSTRACT:

Background

Thiamine administration has been shown to improve survival in a postcardiac arrest animal study. We aimed to evaluate the efficacy of thiamine in comatose out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation.

Methods

A randomized, double-blinded, placebo-controlled study was conducted. Thirty-seven OHCA patients were randomly assigned to receive either thiamine 100 mg every 8 hours or a placebo. The primary outcome was 28-day all-cause mortality.

Results

Over the course of 2 years, 37 patients were randomized to either receive thiamine (n = 20) or a placebo (n = 17). The primary outcome was not different between the groups: 10/20 (50%) in the thiamine group vs. 8/17 (47.1%) in the placebo group (P=0

SUBMITTER: Pradita-Ukrit S 

PROVIDER: S-EPMC7298263 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature