Ontology highlight
ABSTRACT:
SUBMITTER: Allan LA
PROVIDER: S-EPMC7298293 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Allan Lindsey A LA Camacho Reis Magda M Ciossani Giuseppe G Huis In 't Veld Pim J PJ Wohlgemuth Sabine S Kops Geert Jpl GJ Musacchio Andrea A Saurin Adrian T AT
The EMBO journal 20200323 12
Cyclin B:CDK1 is the master kinase regulator of mitosis. We show here that, in addition to its kinase functions, mammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability. Cyclin B1 localises to an expanded region of the outer kinetochore, known as the corona, where it scaffolds the spindle assembly checkpoint (SAC) machinery by binding directly to MAD1. In vitro reconstitutions map the key binding interface to a few acidic residues in the N-terminal regi ...[more]