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Burden of respiratory viral infection in persons with human immunodeficiency virus.


ABSTRACT: This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real-time reverse transcription polymerase chain reaction and primer-independent next-generation sequencing (NGS). Of 82 subjects, respiratory viruses were the most common pathogen identified in 27 (33%), followed by fungus and bacteria in 8 (10%) and 4 (5%) subjects, respectively. Among subjects with RVI, 11 (41%) required ICU admission and 16 (59%) required mechanical ventilation. The proportion of respiratory viruses identified, and the associated complicated hospital course highlights the significant role that RVIs play in the lung health of PLH.

SUBMITTER: Sellers SA 

PROVIDER: S-EPMC7298306 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Burden of respiratory viral infection in persons with human immunodeficiency virus.

Sellers Subhashini A SA   Dover Kenton L KL   Bailey Aubrey G AG   Cheves Avery A   Eason Anthony B AB   Popowitch Elena B EB   Miller Melissa B MB   Wohl David A DA   Dittmer Dirk P DP   Fischer William A WA  

Influenza and other respiratory viruses 20200309 4


This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real-time reverse transcription polymerase chain reaction and primer-independent next-generation sequencing (NGS). Of 82 subjects, respiratory viruses were the most common pathogen identified in 27 (33%), followed by fungus and bacteria in 8 (10%) and 4 (5%) subjects, respectively. Among subjects with RVI, 11 (41%) required ICU ad  ...[more]

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