Are sex discordant outcomes in COVID-19 related to sex hormones?
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ABSTRACT:
SUBMITTER: Strope JD
PROVIDER: S-EPMC7298487 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
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Are sex discordant outcomes in COVID-19 related to sex hormones?
Strope Jonathan D JD Chau Cindy H CH Figg William D WD
Seminars in oncology 20200617 5
COVID-19 has a clear sex disparity in clinical outcome. Globally, infection rates between men and women are similar; however, men are more likely to have more severe disease and are more likely to die. The causes for this disparity are currently under investigation and are most likely multifactorial. Sex hormones play an important role in the immune response with estrogen seen as immune boosting and testosterone as immunosuppressing. Additionally, an important protease involved in viral entry, T ...[more]
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